Gastric cancer in individuals with Li-Fraumeni syndrome
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055281" target="_blank" >RIV/00216224:14110/11:00055281 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/11:#0000166
Result on the web
<a href="http://dx.doi.org/10.1097/GIM.0b013e31821628b6" target="_blank" >http://dx.doi.org/10.1097/GIM.0b013e31821628b6</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/GIM.0b013e31821628b6" target="_blank" >10.1097/GIM.0b013e31821628b6</a>
Alternative languages
Result language
angličtina
Original language name
Gastric cancer in individuals with Li-Fraumeni syndrome
Original language description
Li-Fraumeni syndrome is a rare hereditary cancer syndrome associated with germline mutations in the TP53 gene. Although sarcomas, brain tumors, leukemias, breast and adrenal cortical carcinomas are typically recognized as Li-Fraumeni syndrome-associatedtumors, the occurrence of gastrointestinal neoplasms has not been fully evaluated. In this analysis, we investigated the frequency and characteristics of gastric cancer in Li-Fraumeni syndrome. Methods: Pedigrees and medical records of 62 TP53 mutation-positive families were retrospectively reviewed from the Dana-Farber/National Cancer Institute Li-Fraumeni syndrome registry. We identified subjects with gastric cancer documented either by pathology report or death certificate and performed pathology review of the available specimens. Results: Among 62 TP53 mutation-positive families, there were 429 cancer-affected individuals. Gastric cancer was the diagnosis in the lineages of 21 (4.9%) subjects from 14 families (22.6%).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Genetics In Medicine
ISSN
1098-3600
e-ISSN
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Volume of the periodical
13
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
651-657
UT code for WoS article
000292538200008
EID of the result in the Scopus database
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