A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F11%3A00055290" target="_blank" >RIV/00216224:14110/11:00055290 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/11:#0000187
Result on the web
<a href="http://dx.doi.org/10.1002/ijc.25420" target="_blank" >http://dx.doi.org/10.1002/ijc.25420</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ijc.25420" target="_blank" >10.1002/ijc.25420</a>
Alternative languages
Result language
angličtina
Original language name
A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis
Original language description
Interaction between CD40 and its ligand, CD154, has a key function in immune regulation. Recent experimental data support a role of deregulated CD40 signalling in lymphomagenesis. Data from earlier studies that are part of this pooling study implicate afunctional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma. Here, the association of this variant with non-Hodgkin lymphoma (NHL) risk was replicated in a European multicenter study of 855 NHL cases and 1,206 controls. In the combined analysis of 2,617 cases and 3,605 controls, carrying the TT genotype was associated with an increased risk for all NHL (OR = 1.4; p for linear trend = 0.00009), diffuse large B-cell lymphoma (OR = 1.6; p for linear trend = 0.002) and follicular lymphoma (OR 5 1.6; p for linear trend = 0.001). These data suggest a possible role of this functional polymorphism in lymphomas originating within the germinal center.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Cancer
ISSN
0020-7136
e-ISSN
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Volume of the periodical
128
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
1481-1485
UT code for WoS article
000287158700024
EID of the result in the Scopus database
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