Estimation of rate constants of drug binding to open channels of cardiac transient outward current

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059510" target="_blank" >RIV/00216224:14110/12:00059510 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4149/gpb_2012_013" target="_blank" >http://dx.doi.org/10.4149/gpb_2012_013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/gpb_2012_013" target="_blank" >10.4149/gpb_2012_013</a>

Result language
angličtina
Original language name
Estimation of rate constants of drug binding to open channels of cardiac transient outward current
Original language description
An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current Ito, is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are calculated from the time constants resulting from an approximation of the time course of apparent inactivation of the recorded Ito by two exponentials in the absence and by three exponentials in the presence, ofa blocking agent. The model study confirmed significantly higher accuracy in comparison with the existing electrophysiological method.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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