Ultrasound and Cisplatin Combined Treatment of Human Melanoma Cells A375?the Study of Sonodynamic Therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060116" target="_blank" >RIV/00216224:14110/12:00060116 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.ultrasmedbio.2012.02.006" target="_blank" >http://dx.doi.org/10.1016/j.ultrasmedbio.2012.02.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ultrasmedbio.2012.02.006" target="_blank" >10.1016/j.ultrasmedbio.2012.02.006</a>
Alternative languages
Result language
angličtina
Original language name
Ultrasound and Cisplatin Combined Treatment of Human Melanoma Cells A375?the Study of Sonodynamic Therapy
Original language description
Sonodynamic therapy, an effect of low-power ultrasound field and the anticancer drug cisplatin was studied in vitro on human melanoma cells A375. The viability of cells has been studied by standard MTT test according to different modes of treatment: application of cisplatin alone, exposure of ultrasound field alone, exposure to ultrasound followed by cisplatin, and application of cisplatin followed by exposure to ultrasound. Ultrasound was used at a therapeutical intensity of 1 Wcm-2 for 10 min. Concentration of cisplatin in the cell suspension was always 2,3 mikroM. The results show that sonodynamic therapy is one of the possibilities how to intensify standard cytostatic therapy. This conclusion is supported by reducing the viability of studied cells,especially 72 hours after the treatment. The time sequence of application of ultrasonic field and cytostatics appears to be a significant factor affecting the changes in cell?s viability.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
BO - Biophysics
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ultrasound in Medicine and Biology
ISSN
0301-5629
e-ISSN
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Volume of the periodical
38
Issue of the periodical within the volume
7
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
1205-1211
UT code for WoS article
000304995600014
EID of the result in the Scopus database
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