HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060120" target="_blank" >RIV/00216224:14110/12:00060120 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/12:A13016N1 RIV/00209805:_____/12:#0000365
Result on the web
<a href="http://dx.doi.org/10.1186/1746-1596-7-58" target="_blank" >http://dx.doi.org/10.1186/1746-1596-7-58</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1746-1596-7-58" target="_blank" >10.1186/1746-1596-7-58</a>
Alternative languages
Result language
angličtina
Original language name
HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma
Original language description
Background: Renal cell carcinoma (RCC) is characterized by its resistance to radiotherapy and/or chemotherapy. On the other hand, it is an immunogenic tumor - it is able to stimulate antitumor responses. A prognostic significance of HLA-G expression by neoplastic cells in RCC is not well characterized; significance HLA-E expression in RCC is not characterized at all. Methods: In our study, we evaluated the expression of HLA-G and HLA-E specific mRNA transcripts produced by neoplastic cells in 38 cases of RCC and in 10 samples of normal kidney parenchyma. The results were statistically correlated with various clinico-pathological parameters. Results: We confirmed that HLA-G is downregulated in normal kidney tissue; if it is up-regulated in RCC, then itis connected to worse prognosis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diagnostic Pathology
ISSN
1746-1596
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
58
UT code for WoS article
000306977900001
EID of the result in the Scopus database
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