Association between three single nucleotide polymorphisms in eotaxin (CCL 11) gene, hexanucleotide repetition upstream, severity and course of coronary atherosclerosis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060378" target="_blank" >RIV/00216224:14110/12:00060378 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/12:#0000930 RIV/00159816:_____/12:#0000813
Result on the web
<a href="http://www.springerlink.com/content/km07l108721m1m24/?MUD=MP" target="_blank" >http://www.springerlink.com/content/km07l108721m1m24/?MUD=MP</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13353-012-0104-2" target="_blank" >10.1007/s13353-012-0104-2</a>

Result language
angličtina
Original language name
Association between three single nucleotide polymorphisms in eotaxin (CCL 11) gene, hexanucleotide repetition upstream, severity and course of coronary atherosclerosis
Original language description
The impact of three single-nucleotide polymorphisms in eotaxin (SCYA11) gene promoter (- 426C/T and - 384A/G) and first exon (67G/A) and recently described hexanucleotide (GAAGGA)n 10.9 kb upstream on coronary atherosclerosis was investigated. Elective coronary angiography of 1050 consecutive subjects was performed. All patients were genotyped for the three SNPs. In a subset of the first 472 samples, the number of (GAAGGA)n repetitions was determined. For further evaluation, short and long variants weredistinguished; the borderline corresponded with the median value of all alleles: 8 and less repetitions were considered as short sequence, 9 and more repetitions as long. Patients with bronchial asthma or insignificant atherosclerosis were excluded; theremaining group of 933 subjects was further investigated. Patients were grouped according to the form of CAD (ACS vs. stable angina) and the number of diseased vessels.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
—

Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
S - Specificky vyzkum na vysokych skolach

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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