Effect of zinc(II) ions on the expression of pro- and anti-apoptotic factors in high-grade prostate carcinoma cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060405" target="_blank" >RIV/00216224:14110/12:00060405 - isvavai.cz</a>

Alternative codes found

RIV/62156489:43210/12:00189504 RIV/00216208:11130/12:8203 RIV/62157124:16370/12:43871247 RIV/00216305:26620/12:PU99137 RIV/00064203:_____/12:8203

Result on the web

<a href="http://dx.doi.org/10.3892/or.2012.1897" target="_blank" >http://dx.doi.org/10.3892/or.2012.1897</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3892/or.2012.1897" target="_blank" >10.3892/or.2012.1897</a>

Result language

angličtina

Original language name

Effect of zinc(II) ions on the expression of pro- and anti-apoptotic factors in high-grade prostate carcinoma cells

Original language description

Several typical characteristics of prostate tissue have been identified including the ability to accumulate zinc(II). However, this feature of prostate cells is lost during carcinogenesis and, thus, prostate cells are unable to accumulate zinc(II) ions in high levels. Therefore, we can expect that zinc(II) ions can significantly contribute to the progression of tumour disease and to the ability of prostate cell lines to metastasize. In this study, we aimed our attention on determining the expression ofBcl-2, c-Fos, c-Jun, Ki-67, NF-xB and p53 genes in two prostate cell lines, as the 22Rv1 cell line, a model of aggressive partially androgen-sensitive prostate cancer and the PNT1A cell line, a normal prostate cell line model. Moreover, we were interested in the mechanisms through which exposure of these cell lines to zinc(II) ions could influence expression of the above-mentioned genes.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Oncology Reports

ISSN

1021-335X

e-ISSN

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Volume of the periodical

28

Issue of the periodical within the volume

3

Country of publishing house

GR - GREECE

Number of pages

9

Pages from-to

806-814

UT code for WoS article

000307210600007

EID of the result in the Scopus database

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