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Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060449" target="_blank" >RIV/00216224:14110/12:00060449 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11120/12:43896924 RIV/65269705:_____/12:#0001912 RIV/00064173:_____/12:43896924

  • Result on the web

    <a href="http://dx.doi.org/10.1016/S0140-6736(11)61940-5" target="_blank" >http://dx.doi.org/10.1016/S0140-6736(11)61940-5</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/S0140-6736(11)61940-5" target="_blank" >10.1016/S0140-6736(11)61940-5</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial

  • Original language description

    Background The intensity of chemotherapy and need for additional radiotherapy in patients with advanced stage Hodgkin's lymphoma has been unclear. We did a prospective randomised clinical trial comparing two reduced-intensity chemotherapy variants with our previous standard regimen. Chemotherapy was followed by PET-guided radiotherapy. Methods In this parallel group, open-label, multicentre, non-inferiority trial (HD15), 2182 patients with newly diagnosed advanced stage Hodgkin's lymphoma aged 18-60 years were randomly assigned to receive either eight cycles of BEACOPP(escalated) (8xB(esc) group), six cycles of BEACOPP(escalated) (6xB(esc) group), or eight cycles of BEACOPP(14) (8xB(14) group). Randomisation (1:1:1) was done centrally by stratified minimisation. Non-inferiority of the primary endpoint, freedom from treatment failure, was assessed using repeated CIs for the hazard ratio (HR) according to the intention-to-treat principle. Patients with a persistent mass after chemotherap

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Lancet

  • ISSN

    0140-6736

  • e-ISSN

  • Volume of the periodical

    379

  • Issue of the periodical within the volume

    9828

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    1791-1799

  • UT code for WoS article

    000303937700033

  • EID of the result in the Scopus database