Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00060449" target="_blank" >RIV/00216224:14110/12:00060449 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/12:43896924 RIV/65269705:_____/12:#0001912 RIV/00064173:_____/12:43896924
Result on the web
<a href="http://dx.doi.org/10.1016/S0140-6736(11)61940-5" target="_blank" >http://dx.doi.org/10.1016/S0140-6736(11)61940-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S0140-6736(11)61940-5" target="_blank" >10.1016/S0140-6736(11)61940-5</a>

Result language
angličtina
Original language name
Reduced-intensity chemotherapy and PET-guided radiotherapy in patients with advanced stage Hodgkin's lymphoma (HD15 trial): a randomised, open-label, phase 3 non-inferiority trial
Original language description
Background The intensity of chemotherapy and need for additional radiotherapy in patients with advanced stage Hodgkin's lymphoma has been unclear. We did a prospective randomised clinical trial comparing two reduced-intensity chemotherapy variants with our previous standard regimen. Chemotherapy was followed by PET-guided radiotherapy. Methods In this parallel group, open-label, multicentre, non-inferiority trial (HD15), 2182 patients with newly diagnosed advanced stage Hodgkin's lymphoma aged 18-60 years were randomly assigned to receive either eight cycles of BEACOPP(escalated) (8xB(esc) group), six cycles of BEACOPP(escalated) (6xB(esc) group), or eight cycles of BEACOPP(14) (8xB(14) group). Randomisation (1:1:1) was done centrally by stratified minimisation. Non-inferiority of the primary endpoint, freedom from treatment failure, was assessed using repeated CIs for the hazard ratio (HR) according to the intention-to-treat principle. Patients with a persistent mass after chemotherap
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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