TGF-beta - an excellent servant but a bad master
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00061365" target="_blank" >RIV/00216224:14110/12:00061365 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/12:#0001849
Result on the web
<a href="http://www.translational-medicine.com/content/10/1/183" target="_blank" >http://www.translational-medicine.com/content/10/1/183</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1479-5876-10-183" target="_blank" >10.1186/1479-5876-10-183</a>
Alternative languages
Result language
angličtina
Original language name
TGF-beta - an excellent servant but a bad master
Original language description
The transforming growth factor (TGF-beta) family of growth factors controls an immense number of cellular responses and figures prominently in development and homeostasis of most human tissues. Work over the past decades has revealed significant insightinto the TGF-beta signal transduction network, such as activation of serine/threonine receptors through ligand binding, activation of SMAD proteins through phosphorylation, regulation of target genes expression in association with DNA-binding partners and regulation of SMAD activity and degradation. Disruption of the TGF-beta pathway has been implicated in many human diseases, including solid and hematopoietic tumors. As a potent inhibitor of cell proliferation, TGF-beta acts as a tumor suppressor; however in tumor cells, TGF-beta looses anti-proliferative response and become an oncogenic factor.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Translational Medicine
ISSN
1479-5876
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
"art. 183"
Country of publishing house
GB - UNITED KINGDOM
Number of pages
24
Pages from-to
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UT code for WoS article
000311108500001
EID of the result in the Scopus database
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