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Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00062695" target="_blank" >RIV/00216224:14110/12:00062695 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    čeština

  • Original language name

    Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?

  • Original language description

    Vitamin D shows the ability to inhibit mitogen-activated protein kinase (MAPK) and thus negative growth regulation of mammary carcinoma cells both in vivo and in vitro. The mechanism of action is interpreted in two ways: it regulates gene transcription of the gene through the specific intracellular vitamin D receptor (VDR) and, by means of activation of transmembrane transfer, it induces a fast non-transcriptional response of the character of modification of growth factors and peptide hormones. Based onthese activities there occurs an antiproliferative, proapoptotic influence on many cell lines.. In discussions on the mutual relationship between vitamin D and tumorous growth there frequently appears the theme of exposure to solar radiation as a significant source of vitamin D for man in contrast to the rising occurrence of malignant melanoma, in whose pathogenesis exposure to solar radiation plays indeed an important role.

  • Czech name

    Vitamin D and tumours - sun and tumours - vitamin D and sun. Triangle of conflict or synergy?

  • Czech description

    Vitamin D shows the ability to inhibit mitogen-activated protein kinase (MAPK) and thus negative growth regulation of mammary carcinoma cells both in vivo and in vitro. The mechanism of action is interpreted in two ways: it regulates gene transcription of the gene through the specific intracellular vitamin D receptor (VDR) and, by means of activation of transmembrane transfer, it induces a fast non-transcriptional response of the character of modification of growth factors and peptide hormones. Based onthese activities there occurs an antiproliferative, proapoptotic influence on many cell lines.. In discussions on the mutual relationship between vitamin D and tumorous growth there frequently appears the theme of exposure to solar radiation as a significant source of vitamin D for man in contrast to the rising occurrence of malignant melanoma, in whose pathogenesis exposure to solar radiation plays indeed an important role.

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    FE - Other fields of internal medicine

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů