Mutation analysis of RyR2 gene in patients after arrhythmic storm

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00064650" target="_blank" >RIV/00216224:14110/12:00064650 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.crvasa.2012.03.003" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2012.03.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.crvasa.2012.03.003" target="_blank" >10.1016/j.crvasa.2012.03.003</a>

Result language

angličtina

Original language name

Mutation analysis of RyR2 gene in patients after arrhythmic storm

Original language description

Introduction: Mutations of RyR2 gene encoding calcium channel of sarcoplazmatic reticulum are the cause of congenital catecholaminergic polymorphic ventricular tachycardia. The aim of this study was to test the hypothesis that RyR2 variants can increaseoccurrence of malignant arrhythmias in patients with structural heart diseases. Methods: The investigated group consisted of 36 patients with structural heart diseases with ICD implanted who suffered arrhythmic storm. In the control group there were 141patients with coronary artery disease who were hospitalized at our department owing to an acute coronary event and they were alive at least 3 years after the index event. Thus, they could be considered as a group with a low risk of sudden cardiac death.In all of them mutation analysis of RyR2 gene was performed. Results: We detected 16 different sequence changes of RyR2 gene in both groups.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cor et Vasa

ISSN

0010-8650

e-ISSN

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Volume of the periodical

54

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

"E84"-"E87"

UT code for WoS article

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EID of the result in the Scopus database

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