Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00065607" target="_blank" >RIV/00216224:14110/13:00065607 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/1479-5876-11-77" target="_blank" >http://dx.doi.org/10.1186/1479-5876-11-77</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1479-5876-11-77" target="_blank" >10.1186/1479-5876-11-77</a>
Alternative languages
Result language
angličtina
Original language name
Clinical implication of centrosome amplification and expression of centrosomal functional genes in multiple myeloma
Original language description
Background: Multiple myeloma (MM) is a low proliferative tumor of postgerminal center plasma cell (PC). Centrosome amplification (CA) is supposed to be one of the mechanisms leading to chromosomal instability. Also, CA is associated with deregulation ofcell cycle, mitosis, DNA repair and proliferation. The aim of our study was to evaluate the prognostic significance and possible role of CA in pathogenesis and analysis of mitotic genes as mitotic disruption markers. Design and methods: A total of 173 patients were evaluated for this study. CD138+ cells were separated by MACS. Immunofluorescent labeling of centrin was used for evaluation of centrosome amplification in PCs. Interphase FISH with cytoplasmic immunoglobulin light chain staining (cIg FISH) and qRT-PCR were performed on PCs. Results: Based on the immunofluorescent staining results, all patients were divided into two groups: CA positive (38.2%) and CA negative (61.8%).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
ED - Physiology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Translational Medicine
ISSN
1479-5876
e-ISSN
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Volume of the periodical
11
Issue of the periodical within the volume
77
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000317292200001
EID of the result in the Scopus database
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