Molecular heterogeneity and centrosome-associated genes in multiple myeloma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00065610" target="_blank" >RIV/00216224:14110/13:00065610 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.3109/10428194.2013.764416" target="_blank" >http://dx.doi.org/10.3109/10428194.2013.764416</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/10428194.2013.764416" target="_blank" >10.3109/10428194.2013.764416</a>
Alternative languages
Result language
angličtina
Original language name
Molecular heterogeneity and centrosome-associated genes in multiple myeloma
Original language description
In multiple myeloma (MM), biologic complexity originates from complex oncogenic processes involving somatic acquisition of myriad mutations coupled with genetic variability within the host. This pathogenically determined molecular heterogeneity predetermines clinical intricacy. In this study, we performed gene expression profi ling (GEP) focusing on centrosome-related genes to determine the molecular heterogeneity for centrosomeassociated genes in patients with MM. We identifi ed the gene pattern with an impact on myeloma pathogenesis. According to expression tendency, three subgroups of patients were established. The revealed molecular signature is related to overall survival as well as to clinical parameters and the International Staging System. Associations with integral clinical parameters allow us to proclaim the impact of the revealed functional gene set in MM genesis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Leukemia & Lymphoma
ISSN
1042-8194
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
9
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
1982-1988
UT code for WoS article
000323492400022
EID of the result in the Scopus database
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