Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00067608" target="_blank" >RIV/00216224:14110/13:00067608 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/13:#0002135
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0165572812003177" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0165572812003177</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jneuroim.2012.10.014" target="_blank" >10.1016/j.jneuroim.2012.10.014</a>
Alternative languages
Result language
angličtina
Original language name
Association of HLA-DRB1*1501 tagging rs3135388 gene polymorphism with multiple sclerosis
Original language description
We investigated the HLA-DRB1*1501 tagging rs3135388 gene polymorphism and its association with multiple sclerosis (MS) susceptibility, disability and gender differences. The study group consisted of 306 MS patients and 137 healthy individuals. A significant difference in genotype distribution (Pg = 3.06 x 10 - 9) and allele frequency (Pa = 6.08 x 10- 10) between MS patients and controls was demonstrated. The homozygotes AA and heterozygotes GA were more frequent in MS patients (OR = 4.27, 95% CI: 2.64-6.92). A significant difference between female MS patients and female controls in genotype distribution (Pg = 1.3 x 10- 8) and allele frequency (Pa = 2.82 x 10- 9); (OR = 5.11, 95% CI: 2.86-9.15) was also proved. Our results indicate that the distributionof the rs3135388 gene polymorphism is a risk factor for MS susceptibility in the Czech female population.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Neuroimmunology
ISSN
0165-5728
e-ISSN
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Volume of the periodical
255
Issue of the periodical within the volume
1-2
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
92-96
UT code for WoS article
000315014700013
EID of the result in the Scopus database
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