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Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00068502" target="_blank" >RIV/00216224:14110/13:00068502 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.peptides.2013.04.011" target="_blank" >http://dx.doi.org/10.1016/j.peptides.2013.04.011</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.peptides.2013.04.011" target="_blank" >10.1016/j.peptides.2013.04.011</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children

  • Original language description

    Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission. The second objective was to determine optimal cut-off value and quantify diagnostic characteristics of TFF2 between controls and patients with various septic states. The study included 57 children aged 0-19 years, with expected or proven SIRS and septic condition. The degree of severity was evaluated according to PELOD Score (Pediatric Logistic Organ Dysfunction).

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2013

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Peptides

  • ISSN

    0196-9781

  • e-ISSN

  • Volume of the periodical

    46

  • Issue of the periodical within the volume

    August

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    1-5

  • UT code for WoS article

    000322628600001

  • EID of the result in the Scopus database