Anemia as a predictor of response to antiviral therapy in chronic hepatitis C

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069218" target="_blank" >RIV/00216224:14110/13:00069218 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11110/13:10173553 RIV/00064165:_____/13:10173553

Result on the web

<a href="http://dx.doi.org/10.4149/BLL_2013_044" target="_blank" >http://dx.doi.org/10.4149/BLL_2013_044</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/BLL_2013_044" target="_blank" >10.4149/BLL_2013_044</a>

Result language

angličtina

Original language name

Anemia as a predictor of response to antiviral therapy in chronic hepatitis C

Original language description

Background: The standard therapy for chronic HCV infection is the administration of pegylated interferons in combination with ribavirin. Anemia is a dose-dependent side-effect of ribavirin administration. The degree of anemia could be indicative of the individual exposure to ribavirin. Aims: 1) To evaluate the correlation of HGB level decreases at specified time-points with a sustained virological response during the antiviral treatment. 2) To compare these parameters with the virological predictors forresponses. Methods: A retrospective analysis of cohort, which comprised 164 patients treated with standard therapy at a tertiary center in Prague, Czech Republic. Results: We identified several predictive factors for a sustained virological response infemales: baseline HGB level &lt;= 140 g/l (p=0.025), maximum drop from baseline &gt;40 g (p=0.039), and a HGB drop in week 4 &gt;30 g (p=0.044). There was only one predictor identified for males: reaching the lowest HGB level after week 1

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EE - Microbiology, virology

OECD FORD branch

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Project

<a href="/en/project/NR9412" target="_blank" >NR9412: Role of heme oxygenase in the pathogenesis of hepatocelular injury in chronic HCV infection</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bratislava Medical Journal - Bratislavské lékarske listy

ISSN

0006-9248

e-ISSN

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Volume of the periodical

114

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

5

Pages from-to

213-217

UT code for WoS article

000318058700006

EID of the result in the Scopus database

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