Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00069862" target="_blank" >RIV/00216224:14110/13:00069862 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1186/1471-2407-13-439" target="_blank" >http://dx.doi.org/10.1186/1471-2407-13-439</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/1471-2407-13-439" target="_blank" >10.1186/1471-2407-13-439</a>

Result language
angličtina
Original language name
Context-dependent interpretation of the prognostic value of BRAF and KRAS mutations in colorectal cancer
Original language description
Background: The mutation status of the BRAF and KRAS genes has been proposed as prognostic biomarker in colorectal cancer. Of them, only the BRAF V600E mutation has been validated independently as prognostic for overall survival and survival after relapse, while the prognostic value of KRAS mutation is still unclear. We investigated the prognostic value of BRAF and KRAS mutations in various contexts defined by stratifications of the patient population.Methods: We retrospectively analyzed a cohort of patients with stage II and III colorectal cancer from the PETACC-3 clinical trial (N = 1,423), by assessing the prognostic value of the BRAF and KRAS mutations in subpopulations defined by all possible combinations of the following clinico-pathological variables: T stage, N stage, tumor site, tumor grade and microsatellite instability status.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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