Impaired bioavailability and antiplatelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR)
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00071680" target="_blank" >RIV/00216224:14110/13:00071680 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/13:00060634 RIV/62157124:16370/13:43872242
Result on the web
<a href="http://dx.doi.org/10.1007/s00228-012-1360-0" target="_blank" >http://dx.doi.org/10.1007/s00228-012-1360-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00228-012-1360-0" target="_blank" >10.1007/s00228-012-1360-0</a>
Alternative languages
Result language
angličtina
Original language name
Impaired bioavailability and antiplatelet effect of high-dose clopidogrel in patients after cardiopulmonary resuscitation (CPR)
Original language description
Purpose Bioavailability of clopidogrel in the form of crushed tablets administered via nasogastric tube (NGT) has not been established in patients after cardiopulmonary resuscitation. Therefore, we performed a study comparing pharmacokinetic and pharmacodynamic response to high loading dose of clopidogrel in critically ill patients after cardiopulmonary resuscitation (CPR) with patients scheduled for elective coronary angiography with stent implantation. Methods In the NGT group (nine patients, after cardiopulmonary resuscitation, mechanically ventilated, therapeutic hypothermia), clopidogrel was administered in the form of crushed tablets via NGT. Ten patients undergoing elective coronary artery stenting took clopidogrel per os (po) in the form of intact tablets. Pharmacokinetics of clopidogrel was measured with high-performance liquid chromatography (HPLC) before and at 0.5, 1, 6, 12, 24 h after administration of a loading dose of 600 mg.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
ISSN
0031-6970
e-ISSN
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Volume of the periodical
69
Issue of the periodical within the volume
3
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
309-317
UT code for WoS article
000317335200002
EID of the result in the Scopus database
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