Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F13%3A00071767" target="_blank" >RIV/00216224:14110/13:00071767 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1615/CritRevImmunol.2013008033" target="_blank" >http://dx.doi.org/10.1615/CritRevImmunol.2013008033</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1615/CritRevImmunol.2013008033" target="_blank" >10.1615/CritRevImmunol.2013008033</a>
Alternative languages
Result language
angličtina
Original language name
Therapeutic Dendritic Cell-Based Cancer Vaccines: The State of the Art
Original language description
Dendritic cells (DCs) are the most potent professional antigen-presenting cells, capable of initiating proper adaptive immune responses. Although tumor-infiltrating DCs are able to recognize cancer cells and uptake tumor antigens, they often have impaired functions because of the immunosuppressive tumor milieu. Therefore, DCs are targeted by therapeutic means either in vivo or ex vivo to facilitate tumor antigen presentation to T cells and induce or promote efficient antitumor immune responses in cancerpatients. This immunotherapeutical approach is defined as specific active tumor immunotherapy or therapeutic cancer vaccination. In this review we briefly discuss general aspects of DC biology, followed by a thorough description of the current knowledgeand optimization trends of DC vaccine production ex vivo, including various approaches for the induction of proper DC maturation and efficient loading with tumor antigens.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EC - Immunology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
CRITICAL REVIEWS IN IMMUNOLOGY
ISSN
1040-8401
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
59
Pages from-to
489-547
UT code for WoS article
000326204600002
EID of the result in the Scopus database
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