Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00073433" target="_blank" >RIV/00216224:14110/14:00073433 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/14:00061494
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2014_008" target="_blank" >http://dx.doi.org/10.4149/neo_2014_008</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/neo_2014_008" target="_blank" >10.4149/neo_2014_008</a>
Alternative languages
Result language
angličtina
Original language name
Incidence of cytogenetic aberrations in two B lineage subpopulations in multiple myeloma patients analyzed by combination of whole-genome profiling and FISH
Original language description
Multiple myeloma (MM) is an incurable malignant disease of the terminal developmental stage of B-lymphocytes. While genetic heterogeneity of MM is widely described, little is known about its genetic basis as well as primary damage during plasma cells (PC) development. In this study, we focused on genome-wide screening of DNA copy number changes using oligonucleotide-based array-CGH together with I-FISH of the IgH locus rearrangements in pair samples of bone marrow B-cells (CD19+) and CD138+ PC from newly diagnosed MM patients. The IgH disruption was found in 8.9% (4/45) of CD19+ samples and in 57.8% (26/45) of CD138+ samples. The genomic profiling using array-CGH identified copy number alterations (CNAs) in 10% (2/20) of CD19+ samples in regions knownto be important for MM pathogenesis. In contrast, we found CNAs in 100% (16/16) of CD138+ samples.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
61
Issue of the periodical within the volume
1
Country of publishing house
SK - SLOVAKIA
Number of pages
8
Pages from-to
48-55
UT code for WoS article
000329769500007
EID of the result in the Scopus database
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