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Nestin expression throughout multistep pathogenesis of multiple myeloma

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00073562" target="_blank" >RIV/00216224:14110/14:00073562 - isvavai.cz</a>

  • Alternative codes found

    RIV/61988987:17110/14:A1501CG9 RIV/65269705:_____/14:00061547 RIV/00843989:_____/14:E0104255

  • Result on the web

    <a href="http://dx.doi.org/10.1111/bjh.12689" target="_blank" >http://dx.doi.org/10.1111/bjh.12689</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/bjh.12689" target="_blank" >10.1111/bjh.12689</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Nestin expression throughout multistep pathogenesis of multiple myeloma

  • Original language description

    The stem cell marker nestin (NES) is found in dividing cells of developing and regenerating tissues. Upon terminal differentiation, NES expression is diminished but may be re-expressed following injury or in cancer. Surprisingly, we recently confirmed NES as a tumour-specific marker for mature CD138(+)38(+) plasma cells (PC) in multiple myeloma (MM). The present study analysed NES expression throughout the spectrum of MM developmental stages, starting with individuals with no haematological malignancy,through monoclonal gammopathy of undetermined significance (MGUS) and MM to plasma cell leukaemia (PCL) and MM cell lines. NES was analysed in bone marrow PC of 163 MM, four PCL and nine MGUS patients, 10 individuals with no haematological malignancy and6 myeloma cell lines (OPM-2, RPMI-8226, MOLP-8, U-266, EJM, NCI-H929) by flow cytometry and/or real-time polymerase chain reaction or immunochemistry. We observed a tendency of increased NES expression in parallel with disease progressio

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    British journal of haematology

  • ISSN

    0007-1048

  • e-ISSN

  • Volume of the periodical

    164

  • Issue of the periodical within the volume

    5

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    701-709

  • UT code for WoS article

    000331354700011

  • EID of the result in the Scopus database