Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075513" target="_blank" >RIV/00216224:14110/14:00075513 - isvavai.cz</a>
Alternative codes found
RIV/61988987:17110/14:A1501CGG RIV/61989592:15110/14:33150875 RIV/65269705:_____/14:00061545 RIV/00843989:_____/14:E0104313
Result on the web
<a href="http://dx.doi.org/10.3324/haematol.2013.093500" target="_blank" >http://dx.doi.org/10.3324/haematol.2013.093500</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2013.093500" target="_blank" >10.3324/haematol.2013.093500</a>
Alternative languages
Result language
angličtina
Original language name
Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance
Original language description
Multiple myeloma still remains incurable in majority of cases prompting further search for new and better prognostic markers. Emerging evidence has suggested that circulating microRNAs can serve as minimally invasive biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance. In this study, a global analysis of serum microRNAs by TaqMan Low Density arrays was performed, followed by quantitative real-time PCR. The analyses revealed five deregulated microRNAs: miR-744, miR-130a, miR-34a, let-7d and let-7e in monoclonal gammopathy of undetermined significance, newly diagnosed and relapsed multiple myeloma when compared to healthy donors. Multivariate logistic regression analysis showed that combination of miR-34a and let-7e candistinguish multiple myeloma from healthy donors with sensitivity 80.6% and specificity 86.7% and monoclonal gammopathy of undetermined significance from healthy donors with sensitivity 91.1% and specificity 96.7%.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica/the hematology journal
ISSN
0390-6078
e-ISSN
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Volume of the periodical
99
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
8
Pages from-to
511-518
UT code for WoS article
000336255000022
EID of the result in the Scopus database
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