TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075600" target="_blank" >RIV/00216224:14110/14:00075600 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1038/srep03739" target="_blank" >http://dx.doi.org/10.1038/srep03739</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/srep03739" target="_blank" >10.1038/srep03739</a>
Alternative languages
Result language
angličtina
Original language name
TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo
Original language description
Prostate cancer is the most prevalent cancer in males in developed countries. Tumor suppressor candidate 3 (TUSC3) has been identified as a putative tumor suppressor gene in prostate cancer, though its function has not been characterized. TUSC3 shares homologies with the yeast oligosaccharyltransferase (OST) complex subunit Ost3p, suggesting a role in protein glycosylation. We provide evidence that TUSC3 is part of the OST complex and affects N-linked glycosylation in mammalian cells. Loss of TUSC3 expression in DU145 and PC3 prostate cancer cell lines leads to increased proliferation, migration and invasion as well as accelerated xenograft growth in a PTEN negative background. TUSC3 downregulation also affects endoplasmic reticulum (ER) structure andstress response, which results in increased Akt signaling. Together, our findings provide first mechanistic insight in TUSC3 function in prostate carcinogenesis in general and N-glycosylation in particular.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/7AMB12AT019" target="_blank" >7AMB12AT019: Molecular mechanisms of novel tumor markers in ovarian and prostate cancers</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
4
Issue of the periodical within the volume
"3739"
Country of publishing house
GB - UNITED KINGDOM
Number of pages
9
Pages from-to
1-9
UT code for WoS article
000329849100005
EID of the result in the Scopus database
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