Pathophysiological characterization of drug hypersensitivity to tribenoside
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00075892" target="_blank" >RIV/00216224:14110/14:00075892 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/14:00061357
Result on the web
<a href="http://dx.doi.org/10.2478/s11536-013-0248-4" target="_blank" >http://dx.doi.org/10.2478/s11536-013-0248-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11536-013-0248-4" target="_blank" >10.2478/s11536-013-0248-4</a>
Alternative languages
Result language
angličtina
Original language name
Pathophysiological characterization of drug hypersensitivity to tribenoside
Original language description
Tribenoside is a semisynthetic sugar derivative that is mainly indicated for treatment of chronic venous insufficiency. Up to 10% of patients treated by tribenoside can suffer from skin side effects. The adverse effects usually present as angioedema, urticaria, or maculopapular exanthema. The pathophysiology of the reaction has not as yet been elucidated. In this study, we examined 22 patients with drug eruptions caused by tribenoside. Patch tests were performed to investigate in vivo cellular reactions. Laboratory investigations were carried out by lymphocyte transformation tests and basophil activation tests. We found a positive patch test reaction to tribenoside in one patient. The lymphocyte transformation test elicited a borderline positive reaction in one patient, and the basophil activation test gave a clearly positive reaction in another patient. The diagnosis of drug hypersensitivity reactions is a challenge.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FO - Dermatology and venereology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Central European Journal of Medicine
ISSN
1895-1058
e-ISSN
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Volume of the periodical
9
Issue of the periodical within the volume
1
Country of publishing house
PL - POLAND
Number of pages
10
Pages from-to
159-168
UT code for WoS article
000330986800024
EID of the result in the Scopus database
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