Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076660" target="_blank" >RIV/00216224:14110/14:00076660 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/14:00061155

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Significant association of diastolic dysfunction and heart failure with severe sleep apnea-induced hypoxemia in patients with drug-resistant hypertension

Original language description

Objectives: The aim of this study was to assess the relationship of the severity of myocardial dysfunction to the severity of sleep apnea syndrome (SAS) in patients with drug-resistant hypertension. Methods and Results: Thirty-five patients with drug-resistant hypertension underwent complete overnight polysomnography and comprehensive echocardiography including Doppler tissue imaging and speckle tracking analysis within 24 hours. Severe SAS was defined by the presence of severe SA-induced hypoxemia as indicated by percentage of sleep time with oxygen saturation &lt; 90% (t90)&gt;/= 12%. Heart failure with normal ejection fraction (HFNEF) and t90 &gt;/= 12% were found in 66% and 31% of subjects, respectively. Multivariate regression analysis revealed asignificant and independent association of left atrial volume index (LAVI) with t90 &gt;/= 12% (OR 1.292, CI 1.041-1.604, p = 0.020). Severe SA-induced hypoxemia was found in 11 (48%) patients with HFNEF, but in none of those without HFNE

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FA - Cardiovascular diseases including cardio-surgery

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental and Clinical Cardiology

ISSN

1205-6626

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

8

Country of publishing house

CA - CANADA

Number of pages

14

Pages from-to

3204-3217

UT code for WoS article

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EID of the result in the Scopus database

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