Augmenting Clinical Interpretability of Thiopurine Methyltransferase Laboratory Evaluation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00076840" target="_blank" >RIV/00216224:14110/14:00076840 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/14:#0000506 RIV/00216208:11130/14:10293022 RIV/65269705:_____/14:00061783 RIV/00064203:_____/14:10293022
Result on the web
<a href="http://dx.doi.org/10.1159/000357407" target="_blank" >http://dx.doi.org/10.1159/000357407</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1159/000357407" target="_blank" >10.1159/000357407</a>
Alternative languages
Result language
angličtina
Original language name
Augmenting Clinical Interpretability of Thiopurine Methyltransferase Laboratory Evaluation
Original language description
Objective: Individuals with decreased thiopurine methyltransferase (TPMT) activity are at risk of adverse effects of thiopurine administration whereas its increased activity may inactivate drugs faster. We evaluated genotype-phenotype correlations in patients with suspected hematological malignancies and inflammatory bowel disease from our region based on findings of nonlinear TPMT enzyme kinetics previously unreported. Patients and Methods: The study group comprised 267 individuals. They were screenedfor the most common variants of low TPMT activity. TPMT activity was measured in erythrocytes using the HPLC rate-blanked method. Results: Thirty-three patients (12.4%) were heterozygous (26 were TPMT*1/*3A, 5 TPMT*1/*2, 2 TPMT*1/*3C) and 1 was a compound heterozygote (*2/*3A). Normal and low normal TPMT activities substantially overlapped in wildtype and heterozygous individuals, whereas high activities were found in 29 wild-type genotyped patients.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncology
ISSN
0030-2414
e-ISSN
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Volume of the periodical
86
Issue of the periodical within the volume
3
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
152-158
UT code for WoS article
000335939300004
EID of the result in the Scopus database
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