Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077295" target="_blank" >RIV/00216224:14110/14:00077295 - isvavai.cz</a>

Alternative codes found

RIV/68081707:_____/14:00435165

Result on the web

<a href="http://dx.doi.org/10.1007/s11302-014-9412-9" target="_blank" >http://dx.doi.org/10.1007/s11302-014-9412-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11302-014-9412-9" target="_blank" >10.1007/s11302-014-9412-9</a>

Result language

angličtina

Original language name

Lack of adenosine A(3) receptors causes defects in mouse peripheral blood parameters

Original language description

The role of the adenosine A(3) receptor in hematopoiesis was studied using adenosine A(3) receptor knockout (A(3)AR KO) mice. Hematological parameters of peripheral blood and femoral bone marrow of irradiated and untreated A(3)AR KO mice and their wild-type (WT) counterparts were investigated. Irradiation of the mice served as a defined hematopoiesis-damaging means enabling us to evaluate contingent differences in the pattern of experimentally induced hematopoietic suppression between the A(3)AR KO miceand WT mice. Defects were observed in the counts and/or functional parameters of blood cells in the A(3)AR KO mice. These defects include statistically significantly lower values of blood neutrophil and monocyte counts, as well as those of mean erythrocyte volume, mean erythrocyte hemoglobin, blood platelet counts, mean platelet volume, and plateletcrit, and can be considered to bear evidence of the lack of a positive role played by the adenosine A(3) receptor in the hematopoietic syste

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CE - Biochemistry

OECD FORD branch

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Project

<a href="/en/project/GAP303%2F11%2F0128" target="_blank" >GAP303/11/0128: Role of adenosine A3 receptor signaling in regulation of hematopoiesis: knowledge obtained from adenosine A3 receptor knock-out mice</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Purinergic signalling

ISSN

1573-9538

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

3

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

6

Pages from-to

509-514

UT code for WoS article

000341772500010

EID of the result in the Scopus database

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