Brain tissue oxygen directed management and outcome in the patients with severe traumatic brain injury

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078322" target="_blank" >RIV/00216224:14110/14:00078322 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/14:00061774
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Brain tissue oxygen directed management and outcome in the patients with severe traumatic brain injury
Original language description
Secondary damage is leading but often preventable cause of death in severe TBI. ICP control and treatment of CPP have significantly reduced the mortality. The effect of a brain tissue oxygen directed critical care could improve the 6-month GOS in patients with TBI. METHODS: 50 patients underwent prospective evaluation. They were treated in accordance with a PbtO2 values, maintaining brain oxygen level > 20 mm Hg and control ICP < 20 mm Hg. Outcomes were compared with those in a historical patientcohort. RESULTS: 65% of patients had an initially low PbtO2 and comparatively high ICP. Treatment with the PbtO2 directed protocol resulted in a 44% improvement in mean PbtO2 (p < 0.001), control of ICP and the maintenance of CPP. Persistently low cerebral oxygenation was seen in 37% of patients. Thus elevated ICP and a persistent low PbtO2 represented increasing odds of death.
Czech name
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Czech description
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Project
<a href="/en/project/NT12116" target="_blank" >NT12116: Benefit of brain tissue oximetry targeted therapy in the patients with severe trauma brain injury.</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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