DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078413" target="_blank" >RIV/00216224:14110/14:00078413 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/14:00061794
Result on the web
<a href="http://dx.doi.org/10.1111/eci.12368" target="_blank" >http://dx.doi.org/10.1111/eci.12368</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/eci.12368" target="_blank" >10.1111/eci.12368</a>
Alternative languages
Result language
angličtina
Original language name
DPPIV (CD26) as a novel stem cell marker in Ph plus chronic myeloid leukaemia
Original language description
The concept of leukaemic stem cells (LSCs) has been developed to explain the complex cellular hierarchy and biology of leukaemias and to screen for pivotal targets that can be employed to improve drug therapies through LSC eradication in these patients.Some of the newly discovered LSC markers seem to be expressed in a disease-specific manner and may thus serve as major research tools and diagnostic parameters. A useful LSC marker in chronic myeloid leukaemia (CML) appears to be CD26, also known as dipeptidylpeptidase IV. Expression of CD26 is largely restricted to CD34(+)/CD38(-) LSCs in BCR/ABL1(+) CML, but is not found on LSCs in other myeloid or lymphoid neoplasms, with the exception of lymphoid blast crisis of CML, BCR/ABL1(p210)+ acute lymphoblastic leukaemia, and a very few cases of acute myeloid leukaemia. Moreover, CD26 usually is not expressed on normal bone marrow (BM) stem cells.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
European Journal of Clinical Investigation
ISSN
0014-2972
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1239-1245
UT code for WoS article
000345759100012
EID of the result in the Scopus database
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