Influence of FCRN expression on lung decline and intravenous immunoglobulin catabolism in common variable immunodeficiency patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078472" target="_blank" >RIV/00216224:14110/14:00078472 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/14:00061704

Result on the web

<a href="http://dx.doi.org/10.1111/cei.12529" target="_blank" >http://dx.doi.org/10.1111/cei.12529</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cei.12529" target="_blank" >10.1111/cei.12529</a>

Result language

angličtina

Original language name

Influence of FCRN expression on lung decline and intravenous immunoglobulin catabolism in common variable immunodeficiency patients

Original language description

The neonatal Fc receptor (FcRn) was first described as a receptor-mediating transplacental immunoglobulin (Ig)G transfer from mother to fetus, but it has other significant biological functions. It plays a key role in IgG and albumin homeostasis by efficient protection from catabolism [1]. It binds endocytosed IgG at acidic pH (&lt; 6?5) within endosomes, diverts it from degradation in lysosomes and instead transports the IgG?FcRn complexes back to the cell surface where, at neutral pH (&gt; 7?0), IgG isreleased [1]. This process is highly efficient; FcRn recycles an equivalent amount of albumin and even four times as much IgG as can be produced in a given time [2,3].

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical & Experimental Immunology

ISSN

0009-9104

e-ISSN

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Volume of the periodical

178

Issue of the periodical within the volume

Suppl. S1

Country of publishing house

US - UNITED STATES

Number of pages

2

Pages from-to

103-104

UT code for WoS article

000346976700041

EID of the result in the Scopus database

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