Predictive and prognostic significance of sodium levels in patients with NSCLC treated by Erlotinib
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00078688" target="_blank" >RIV/00216224:14110/14:00078688 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11140/14:10285770 RIV/00669806:_____/14:10285770
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Predictive and prognostic significance of sodium levels in patients with NSCLC treated by Erlotinib
Original language description
Background: Hyponatremia is a well-known phenomenon in cancer patients. The aim of our retrospective study was to assess the relationship of natremia levels to predict treatment with erlotinib and also to assess the prognosis of patients with hyponatremia. Patients and Metods: We analyzed data of 544 patients with advancedstage non-small cell lung cancer (NSCLC) treated with erlotinib. Results: Hyponatremia was measured in 21.5 % of patients before treatment with erlotinib. We found a significant increase in the effectiveness of treatment with erlotinib in patients with normal levels of sodium to hyponatremic patients. Progression-free survival (PFS) and overall survival (OS) were also significantly higher in patients with normal natremia. MultivariateCox model analysis demonstrated that natremia was an independent factor for PFS and OS.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Anticancer Research
ISSN
0250-7005
e-ISSN
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Volume of the periodical
34
Issue of the periodical within the volume
12
Country of publishing house
GR - GREECE
Number of pages
5
Pages from-to
7461-7465
UT code for WoS article
000346689700077
EID of the result in the Scopus database
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