Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082101" target="_blank" >RIV/00216224:14110/15:00082101 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/s10238-014-0294-5" target="_blank" >http://dx.doi.org/10.1007/s10238-014-0294-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s10238-014-0294-5" target="_blank" >10.1007/s10238-014-0294-5</a>
Alternative languages
Result language
angličtina
Original language name
Association of circulating levels of RANTES and -403G/A promoter polymorphism to acute heart failure after STEMI and to cardiogenic shock
Original language description
Chemokines, including RANTES, play a crucial role in the processes of inflammation during cardiovascular disorders, including myocardial infarction, disease progression and complications. This study aimed to evaluate the role of RANTES -403G/A polymorphism and levels in circulation in processes of development and progression of myocardial infarction and cardiogenic shock. A total of 609 patients with ST-segment elevation myocardial infarction, 43 patients with cardiogenic shock and 130 control subjectswere enrolled in the study. RANTES -403G/A promoter polymorphism and baseline serum RANTES levels were analyzed. In the present study, we associated RANTES -403G/A promoter polymorphism with acute heart failure in patients with myocardial infarction (p =0.006) and ejection fraction 3 months after MI onset (p = 0.02). Further, a difference in circulating RANTES levels among controls and STEMI subjects, and a relation of serum levels with acute heart failure was observed (p = 0.03, p = 0.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Medicine
ISSN
1591-8890
e-ISSN
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Volume of the periodical
15
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
10
Pages from-to
405-414
UT code for WoS article
000358775900021
EID of the result in the Scopus database
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