Quantitative analysis of drug losses administered via nasogastric tube - In vitro study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082189" target="_blank" >RIV/00216224:14110/15:00082189 - isvavai.cz</a>

Alternative codes found

RIV/62157124:16370/15:43873856 RIV/00159816:_____/15:00063353

Result on the web

<a href="http://dx.doi.org/10.1016/j.ijpharm.2014.11.065" target="_blank" >http://dx.doi.org/10.1016/j.ijpharm.2014.11.065</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijpharm.2014.11.065" target="_blank" >10.1016/j.ijpharm.2014.11.065</a>

Result language

angličtina

Original language name

Quantitative analysis of drug losses administered via nasogastric tube - In vitro study

Original language description

Purpose: Drug administration through nasogastric tube (NGT) is a standard practice but the real amount of the delivered drug is unknown. Therefore, we designed a study to determine the losses of various dosage forms administered by different methods through NGT. Methods: In vitro model was used. Five different administration methods (A?E) and six dosage forms (simple compressed tablets ? T/S; film coated tablets ? T/FC; enteric coated tablets ? T/EC; capsules with powder filling ? C/P; capsules containing extended release pellets ? C/ER; capsules containing gastro-resistant pellets ? C/GR) were investigated. Measurement was repeated six times for each drug-method combination. The overall losses were determined by gravimetry. In method A partial lossesassociated with each step of drug administration were also determined. Results: Significant drug losses were measured (4?38%).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/LM2013034" target="_blank" >LM2013034: Project CZECRIN within the building of the Czech part of research infrastructure of pan-European importance within the European Research Infrastructure Consortium (ERIC)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International Journal of Pharmaceutics

ISSN

0378-5173

e-ISSN

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Volume of the periodical

478

Issue of the periodical within the volume

1

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

4

Pages from-to

368-371

UT code for WoS article

000348621100041

EID of the result in the Scopus database

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