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Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082786" target="_blank" >RIV/00216224:14110/15:00082786 - isvavai.cz</a>

  • Alternative codes found

    RIV/61988987:17110/15:A1601FXH RIV/00216208:11110/15:10296542 RIV/65269705:_____/15:00063093

  • Result on the web

    <a href="http://dx.doi.org/10.5507/bp.2015.014" target="_blank" >http://dx.doi.org/10.5507/bp.2015.014</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.5507/bp.2015.014" target="_blank" >10.5507/bp.2015.014</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data

  • Original language description

    Background. Multiple myeloma (MM) is characterized by malignant proliferation of plasma cells (PC) which accumulate in the bone marrow (BM). The advent of new drugs has changed the course of the disease from incurable to treatable, but most patients eventually relapse. One group of MM patients (10-15%) is considered high-risk because they relapse within 24 months. Recently, extramedullary relapse of MM (EM) has been observed more frequently. Due to its aggressivity and shorter survival, EM is also considered high-risk. Aims. The goal of this study was to determine if the so-called high-risk genes published by the University of Arkansas group (UAMS) are even more deregulated in EM patients than in high-risk MM patients and if these patients may be considered high-risk. Methods. Nine samples of bone marrow plasma cells from MM patients as well as 9 tumors and 9 bone marrow plasma cells from EM patients were used.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Biomedical Papers of the Faculty of Medicine of Palacký University, Olomouc, Czech Republic

  • ISSN

    1213-8118

  • e-ISSN

  • Volume of the periodical

    159

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    6

  • Pages from-to

    288-293

  • UT code for WoS article

    000359128900020

  • EID of the result in the Scopus database