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Long-term treatment for hyperphenylalaninemia and phenylketonuria: a risk for nutritional vitamin B12 deficiency?

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00083548" target="_blank" >RIV/00216224:14110/15:00083548 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/15:00063753

  • Result on the web

    <a href="http://dx.doi.org/10.1515/jpem-2014-0489" target="_blank" >http://dx.doi.org/10.1515/jpem-2014-0489</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1515/jpem-2014-0489" target="_blank" >10.1515/jpem-2014-0489</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Long-term treatment for hyperphenylalaninemia and phenylketonuria: a risk for nutritional vitamin B12 deficiency?

  • Original language description

    Purpose: The objective of the study was to determine the incidence of vitamin B12 deficiency in patients under longterm treatment for phenylketonuria (PKU) and hyperphenylalaninemia (HPA), as well as its associations with B12 vitamin parameters (holotranscobalamin ? active vitamin B12, serum folate, total plasma homocysteine, and plasma methylmalonic acid concentration). Patients and methods: The group consisted of 51 PKU (n = 29) and HPA (n = 22) patients aged 3?48 years (28 children, 23 adults). Results: A significant difference in serum folate levels was discovered between adult HPA patients and PKU patients (p = 0.004, Mann-Whitney U-test). A significant difference in plasma homocysteine concentrations within the normal levels (p = 0.032, chi2-test) was detected between adult HPA and PKU patients.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FG - Paediatrics

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Pediatric Endocrinology and Metabolism

  • ISSN

    0334-018X

  • e-ISSN

  • Volume of the periodical

    28

  • Issue of the periodical within the volume

    11-12

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    1327-1332

  • UT code for WoS article

    000365044600019

  • EID of the result in the Scopus database