Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084659" target="_blank" >RIV/00216224:14110/15:00084659 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/15:00063770
Result on the web
<a href="http://dx.doi.org/10.1016/S2213-2600(14)70290-5" target="_blank" >http://dx.doi.org/10.1016/S2213-2600(14)70290-5</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/S2213-2600(14)70290-5" target="_blank" >10.1016/S2213-2600(14)70290-5</a>
Alternative languages
Result language
angličtina
Original language name
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
Original language description
Background Sepsis continues to be a major cause of death, disability; and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim ofthis study was to identify genetic variants that influence sepsis survival. Methods We did a genome-wide association study in three independent cohorts of white adult patients admitted to intensive care units with sepsis, severe sepsis, or septic shock (as defined by the International Consensus Criteria) due to pneumonia or intra-abdominal infection (cohorts 1-3, n=2534 patients). The primary outcome was 28 day survival. Results for the cohort of patients with sepsis due to pneumonia were combined in ameta-analysis of 1553 patients from all three cohorts, of whom 359 died within 28 days of admission to the intensive-care unit.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
LANCET RESPIRATORY MEDICINE
ISSN
2213-2600
e-ISSN
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Volume of the periodical
3
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
8
Pages from-to
53-60
UT code for WoS article
000347365900021
EID of the result in the Scopus database
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