N-(2-Hydroxypropyl) Methacrylamide Based Cryogels ? Synthesis and Biomimetic Modification for Stem Cell Applications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084753" target="_blank" >RIV/00216224:14110/15:00084753 - isvavai.cz</a>

Alternative codes found

RIV/61389013:_____/15:00448561 RIV/00159816:_____/15:00063638

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

N-(2-Hydroxypropyl) Methacrylamide Based Cryogels ? Synthesis and Biomimetic Modification for Stem Cell Applications

Original language description

The design of favorable mechanical properties and suitable surface modifications of hydrogels in order to stimulate specific cell response is a great challenge. N-(2-Hydroxypropyl) methacryl-amide (HPMA) was utilized to form macroporous cryogel scaffoldsfor stem cell applications. Furthermore, one group of scaffolds was enhanced by copolymerization of HPMA with methacryloyl-GGGRGDS-OH peptide in an effort to integrate biomimetic adhesion sites. The cryogels were characterized by stiffness and equilibrium swelling measurements as well as by scanning electron microscopy. Cell culture experiments were performed with human adipose-derived stem cells and substrates were found completely non-toxic. Moreover, RGDS-enriched cryogels supported cell attachment,spreading and proliferation, so they can be considered suitable for designed aims.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

64

Issue of the periodical within the volume

Suppl. 1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

9

Pages from-to

"S19"-"S27"

UT code for WoS article

000365010700004

EID of the result in the Scopus database

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