Lenalidomide and dexamethasone for acute light chain-induced renal failure: a phase II study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084781" target="_blank" >RIV/00216224:14110/15:00084781 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/15:00063432
Result on the web
<a href="http://dx.doi.org/10.3324/haematol.2014.115204" target="_blank" >http://dx.doi.org/10.3324/haematol.2014.115204</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3324/haematol.2014.115204" target="_blank" >10.3324/haematol.2014.115204</a>
Alternative languages
Result language
angličtina
Original language name
Lenalidomide and dexamethasone for acute light chain-induced renal failure: a phase II study
Original language description
We prospectively evaluated the activity and tolerance of lenalidomide- dexamethasone in 35 patients with acute light chain- induced renal failure. The lenalidomide dose was adapted to the estimated glomerular filtration rate and dexamethasone was given at high dose in cycle one and at low dose thereafter. Four patients died within the first two cycles, and five discontinued therapy leaving 26 patients for the per- protocol analysis. Responses were observed in 24/ 35 ( 68.6%) patients of the intent- to-treat population. Complete response was noted in seven patients ( 20%), very good partial response in three patients ( 8.6%), partial response in 14 patients ( 40%), and min-imal response in one patient ( 2.9%). Renal response was observed in 16 ( 45.7%)patients: five ( 14.2%) achieved complete, four ( 11.4%) partial and seven ( 20%) minor renal responses. Five of 13 patients who were dialysis dependent at baseline became dialysis independent.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
—
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Haematologica
ISSN
0390-6078
e-ISSN
—
Volume of the periodical
100
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
7
Pages from-to
385-391
UT code for WoS article
000351279900029
EID of the result in the Scopus database
—