Adjuvant Chemotherapy in Patients with Resected Non-Small-Cell- Lung Cancer Treated with Carboplatin and Oral Vinorelbine - SWITCH I Study

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00084853" target="_blank" >RIV/00216224:14110/15:00084853 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Adjuvant Chemotherapy in Patients with Resected Non-Small-Cell- Lung Cancer Treated with Carboplatin and Oral Vinorelbine - SWITCH I Study
Original language description
Background: Adjuvant cisplatinum-based chemotherapy is recommended in patients with stages IB (> 4 cm), IIA, IIB, and IIIA of non small-cell lung cancer (NSCLC) after radical resection. Vinorelbine with cisplatin are preferable drugs in this indication, but the side effects of this treatment were not negligible in big adjuvant trials. Carboplatin with vinorelbine given intravenously switched to orally were applied in a multicentre prospective study SWITCH I to give better comfort, higher tolerabilityand comparable effectivenes as standard adjuvant chemotherapy. The recruitment period started in January 12th, 2005 and lasted till September 5th, 2008. Conclusion: Adjuvant chemotherapy with carboplatinum and vinorelbine given intravenously on the day1 and orally on the day 8 in 21 day regimen appears to be a comfortable and tolerable therapy in radically resected NSCLC.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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