Expression of VEGF-A by neoplastic cells in T-cell lymphoblastic lymphoma: possible therapeutic implications related to immunomodulatory properties of this cytokine
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00085103" target="_blank" >RIV/00216224:14110/15:00085103 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Expression of VEGF-A by neoplastic cells in T-cell lymphoblastic lymphoma: possible therapeutic implications related to immunomodulatory properties of this cytokine
Original language description
Background: VEGF-A, well known for its mechanistic angiogenic effect and as a target for antiangiogenic therapeutic drugs, has also potent immunomodulatory characteristics. Namely, it contributes to blockade of dendritic cells maturation and increases anumber of regulatory T lymphocytes (Treg?s) in blood and tumor tissues. Conclusion: We found expression of VEGF-A in a majority of cases of T-LL. Because of known immunosuppressive properties of VEGFA, possible adding of antiangiogenic drugs to therapeutic armamentarium in T-LL appears warranted.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů