Mesenchymal Stem Cells in the Treatment of Type 1 Diabetes Mellitus

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00085444" target="_blank" >RIV/00216224:14110/15:00085444 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/15:00063196

Result on the web

<a href="http://dx.doi.org/10.1007/s12022-015-9362-y" target="_blank" >http://dx.doi.org/10.1007/s12022-015-9362-y</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s12022-015-9362-y" target="_blank" >10.1007/s12022-015-9362-y</a>

Result language

angličtina

Original language name

Mesenchymal Stem Cells in the Treatment of Type 1 Diabetes Mellitus

Original language description

Diabetes mellitus type 1 is a form of diabetes mellitus that results from the autoimmune destruction of insulin-producing beta cells in the pancreas. The current gold standard therapy for pancreas transplantation has limitations because of the long listof waiting patients and the limited supply of donor pancreas. Mesenchymal stem cells (MSCs), a relatively new potential therapy in various fields, have already made their mark in the young field of regenerative medicine. Recent studies have shown that the implantation of MSCs decreases glucose levels through paracrine influences rather than through direct transdifferentiation into insulin-producing cells. Therefore, these cells may use pro-angiogenic and immunomodulatory effects to control diabetes following the cotransplantation with pancreatic islets. In this review, we present and discuss new approaches of using MSCs in the treatment of diabetes mellitus type 1.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FE - Other fields of internal medicine

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrine Pathology

ISSN

1046-3976

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

95-103

UT code for WoS article

000354617600001

EID of the result in the Scopus database

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