Mast cell stabilization with sodium cromoglycate modulates pulmonary vessel wall remodeling during four-day hypoxia in rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00087223" target="_blank" >RIV/00216224:14110/15:00087223 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/15:00063127 RIV/00216208:11130/15:10295704 RIV/65269705:_____/15:00063127 RIV/00064203:_____/15:10295704

Result on the web

<a href="http://dx.doi.org/10.3109/01902148.2015.1018558" target="_blank" >http://dx.doi.org/10.3109/01902148.2015.1018558</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/01902148.2015.1018558" target="_blank" >10.3109/01902148.2015.1018558</a>

Result language

angličtina

Original language name

Mast cell stabilization with sodium cromoglycate modulates pulmonary vessel wall remodeling during four-day hypoxia in rats

Original language description

Aim of the study: In rats, the environment with low content of oxygen induces hypoxic pulmonary hypertension. Remodeling of pulmonary resistance arteries is particularly triggered by the mast cell degranulation products, e.g., rodent-like interstitial collagenase (matrix metalloproteinase 13). Administration of sodium cromoglycate leads to stabilization of mast cell granules, and thus to the modified remodeling process. Materials and Methods: During four-day hypoxia, we treated rats with sodium cromoglycate. Pulmonary vascular remodeling was assessed as well as counts of periarterial pulmonary mast cells, both total and matrix metalloproteinase 13-positive ones. Results: Four-day hypoxia induced remodeling of both resistance arteries and large conduitarteries. We have found increase in the tunica media thickness of resistance arteries.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FC - Pneumology

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Experimental Lung Research

ISSN

0190-2148

e-ISSN

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Volume of the periodical

41

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

283-292

UT code for WoS article

000357350400005

EID of the result in the Scopus database

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