Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088129" target="_blank" >RIV/00216224:14110/16:00088129 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/16:00066192
Result on the web
<a href="http://dx.doi.org/10.1002/eji.201670200" target="_blank" >http://dx.doi.org/10.1002/eji.201670200</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/eji.201670200" target="_blank" >10.1002/eji.201670200</a>
Alternative languages
Result language
angličtina
Original language name
Interleukin-8 receptor 2 (CXCR2) gene variability in patients with chronic periodontitis alone or in combination with type 2 diabetes mellitus in the Czech population
Original language description
Background: Periodontitis is a chronic inflammatory disease triggered by specific subgingival bacteria. Evidence suggests that diabetes mellitus (DM) may modulate periodontal tissue destruction, e.g. by reducing the polymorphonuclear leukocyte functions, including chemotaxis, adherence and phagocytosis. CXCR2 is a specific receptor for the interleukin-8 (IL-8) that is chemoattractant for neutrophils with an important role in the regulation of inflammatory response. Material and Methods: We analyzed CXCR2 +785C/T (rs2230054), +1208C/T (rs1126579) and +1440A/G (rs1126580) polymorphisms in patients with chronic periodontitis (CP) or CP with type 2 DM (T2DM+CP) and healthy controls and determined their associations with risk of diseases and occurrence of periodontal pathogens. Totally, 575 subjects (170 controls, 325 patients with CP and 80 subjects with T2DM+CP) were genotyped using methods based on polymerase chain reaction (PCR). Bacterial colonization (A. actinomycetemcomitans, P. gingivalis, P.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GB14-37368G" target="_blank" >GB14-37368G: Centre of orofacial development and regeneration</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů