Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088272" target="_blank" >RIV/00216224:14110/16:00088272 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/16:00066193
Result on the web
<a href="http://dx.doi.org/10.4172/2161-1122.C1.006" target="_blank" >http://dx.doi.org/10.4172/2161-1122.C1.006</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4172/2161-1122.C1.006" target="_blank" >10.4172/2161-1122.C1.006</a>
Alternative languages
Result language
angličtina
Original language name
Polymorphisms in genes encoding purinoreceptor and osteoprotegerin and external apical root resorption in children after orthodontic treatment
Original language description
Orthodontically induced external apical root resoption (EARR) is a multifactorial inflammatory disease. Genes encoding proteins, which are involved in the modulation of inflammatory response and bone remodeling, are considered as the “candidate” for EARR. The aim of this study was to analyze possible associations of single nucleotide polymorphisms (SNPs) in the P2RX7 (encoding purinoreceptor) and TNFRSF11B (encoding osteoprotegerin) genes with EARR in Czech children after orthodontic treatment. A total, 99 orthodontically treated patients (69 healthy and 30 with EARR) were enrolled in this case-control study. Genotype determination of P2RX7 +489C/T (rs208294, Tyr155His) and +1068C/T (rs1718119, Thr348Ala), TNFRSF11B -163C/T (rs3102735) and TNFRSF11B +1181C/G (rs2073618, Lys3Asn) was based on polymerase chain reaction using 5 nuclease TaqMan® assays.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GB14-37368G" target="_blank" >GB14-37368G: Centre of orofacial development and regeneration</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů