Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00088835" target="_blank" >RIV/00216224:14110/16:00088835 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/16:00064382
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2015.045" target="_blank" >http://dx.doi.org/10.5507/bp.2015.045</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2015.045" target="_blank" >10.5507/bp.2015.045</a>

Result language
angličtina
Original language name
Serum carboxymethyl-lysine, a dominant advanced glycation end product, is increased in women with gestational diabetes mellitus
Original language description
Aims: The objective of the study was to measure one of the circulating Advanced Glycation End Products (AGEs) - N-(carboxymethyl)lysine (CML) - in a case-control study (n = 307) of pregnant women with gestational diabetes mellitus (GDM) and physiological pregnancies and to ascertain the factors contributing to CML levels and the potential relevance of CML for selected perinatal and postpartum outcomes. Methods: All subjects underwent oGTT between 24th and 30th week of gestation and GDM was diagnosed according to WHO criteria. CML was determined by ELISA using commercial kit. Results: Unadjusted and plasma protein adjusted CML levels were significantly higher in women with GDM compared to healthy controls (P = 0.00043 and P = 1x10-5, respectively, Mann-Whitney). CML was significantly inversely correlated with both pre- and mid-gestational BMI, however, differences between GDM and control group remained significant even after adjustment for BMI.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Project
<a href="/en/project/NT11405" target="_blank" >NT11405: Microbiologic and genetic determinants of the onset and progression of periodontitis in type 1 and 2 diabetics and their reciprocal relationship to diabetes compensation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical
Biomedical Papers of the Faculty of Medicine of Palacký University
ISSN
1213-8118
e-ISSN
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Volume of the periodical
160
Issue of the periodical within the volume
1
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
70-75
UT code for WoS article
000373390800008
EID of the result in the Scopus database
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