SLOW SULFIDE DONOR GYY4137 DIFFERENTIATES NG108-15 NEURONAL CELLS THROUGH DIFFERENT INTRACELLULAR TRANSPORTERS THAN dbcAMP

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00090728" target="_blank" >RIV/00216224:14110/16:00090728 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.neuroscience.2016.03.057" target="_blank" >http://dx.doi.org/10.1016/j.neuroscience.2016.03.057</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.neuroscience.2016.03.057" target="_blank" >10.1016/j.neuroscience.2016.03.057</a>

Result language

angličtina

Original language name

SLOW SULFIDE DONOR GYY4137 DIFFERENTIATES NG108-15 NEURONAL CELLS THROUGH DIFFERENT INTRACELLULAR TRANSPORTERS THAN dbcAMP

Original language description

Cellular differentiation is the process, by which a cell changes from one cell type to another, preferentially to the more specialized one. Calcium fluxes play an important role in this action. Differentiated NG108-15 or PC12 cells serve as models for studying neuronal pathways. NG108-15 cell line is a reliable model of cholinergic neuronal cells. These cells differentiate to a neuronal phenotype due to the dibutyryl cAMP (dbcAMP) treatment. We have shown that a slow sulfide donor-GYY4137-can also act as a differentiating factor in NG108-15 cell line. Calcium is an unavoidable ion required in NG108-15 cell differentiation by both, dbcAMP and GYY4137, since cultivation in EGTA completely prevented differentiation of these cells. In this work we focused primarily on the role of reticular calcium in the process of NG108-15 cell differentiation. We have found that dbcAMP and also GYY4137 decreased reticular calcium concentration by different mechanisms.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

NEUROSCIENCE

ISSN

0306-4522

e-ISSN

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Volume of the periodical

325

Issue of the periodical within the volume

"JUN 14 2016"

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

100-110

UT code for WoS article

000374503200010

EID of the result in the Scopus database

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