Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00092308" target="_blank" >RIV/00216224:14110/16:00092308 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1183/13993003.congress-2016.PA1849" target="_blank" >http://dx.doi.org/10.1183/13993003.congress-2016.PA1849</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1183/13993003.congress-2016.PA1849" target="_blank" >10.1183/13993003.congress-2016.PA1849</a>
Alternative languages
Result language
angličtina
Original language name
Impact of standardized physical exertion on oxidative stress biomarkers in exhaled breath condensate of patients suffering from severe chronic obstructive pulmonary disease - The PHAETON project
Original language description
Chronic obstructive pulmonary disease (COPD) is linked to increased oxidative and nitrative stress (RNOS) in the airways and systemic circulation. RNOS causes damage of fosfolipids and proteins in cellular membrane including airway epithelium. Exhaled breath analysis (EBC) can reflex intensity of RNOS in COPD. We compared concentration of RNOS biomarkers and anti-inflammatory lipoxin A4 (LXA4) in EBC in COPD patients and healthy controls before and after incremental shuttle walk test (ISWT), actigraphy was used to follow average daily steps 1 week before ISWT. In 29 patents with severe COPD (age 62±1,7, FEV1 48,8 ± 15,6%) and 17 age matched healthy controls were during 1 day performed EBC collection, EBC samples were frozen and analyzed by mass spectrometry with liqid chromatography. After EBC sampling subjects underwent ISWT, and then again gave EBC.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
FC - Pneumology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů