No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00093761" target="_blank" >RIV/00216224:14110/16:00093761 - isvavai.cz</a>

Result on the web

<a href="https://oatext.com/pdf/GOD-3-175.pdf" target="_blank" >https://oatext.com/pdf/GOD-3-175.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.15761/GOD.1000175" target="_blank" >10.15761/GOD.1000175</a>

Result language

angličtina

Original language name

No association of the SNP rs1048261 within 3´UTR of HSPB7 with cardiovascular morbidity in patients with psoriasis; a possible effect on miRNA-mediated translational regulation

Original language description

Previous studies have shown an increased risk of cardiovascular diseases in patients with psoriasis. It has also been known that abnormal levels of microRNA (miRNA) contribute to the pathogenesis of psoriasis and its comorbidities. Moreover, single nucleotide polymorphisms(SNPs) within miRNA genes or 3’UTR of the miRNA target genes can alter gene expression and thus contribute to the pathogenesis of the disease. Assess SNP rs1048261 within the 3’UTR of HSPB7 in a large cohort (n=558) of psoriatic patients of Central European Caucasian origin and evaluate its possible role in the increased risk of cardiovascular disease (CVD) in psoriasis patients. This study included 558 patients diagnosed with psoriasis; 30% of the patients had a personal history of CVD. In silico analysis was used to determine a candidate SNP which is associated with a potential impairment of miRNA-mediated translational regulation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FO - Dermatology and venereology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Global Dermatology

ISSN

2056-7863

e-ISSN

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Volume of the periodical

3

Issue of the periodical within the volume

2

Country of publishing house

IT - ITALY

Number of pages

5

Pages from-to

281-285

UT code for WoS article

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EID of the result in the Scopus database

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