The monitoring of antiaggregation effect of acetylsalicylic acid therapy by measuring serum thromboxane B-2 in patients with coronary artery bypass grafting

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00113805" target="_blank" >RIV/00216224:14110/16:00113805 - isvavai.cz</a>

Alternative codes found

RIV/00159816:_____/16:00063636

Result on the web

<a href="https://insights.ovid.com/article/00001721-201606000-00003" target="_blank" >https://insights.ovid.com/article/00001721-201606000-00003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/MBC.0000000000000438" target="_blank" >10.1097/MBC.0000000000000438</a>

Result language

angličtina

Original language name

The monitoring of antiaggregation effect of acetylsalicylic acid therapy by measuring serum thromboxane B-2 in patients with coronary artery bypass grafting

Original language description

Cardiovascular patients take acetylsalicylic acid (ASA) for preventing myocardial infarction and other thromboembolic complications. It is already known that in some patients this therapy is not effective. The aim of this study was to assess the percentage of ASA resistance on the sample of patients with coronary artery bypass grafting. Our study included 105 patients with coronary artery bypass grafting treated with ASA 150 mg/day or lesser. Platelet aggregation was measured by serum thromboxane B-2 level as well as impedance aggregometry from whole blood to determine ASA antiaggregation effect. The percentage of ASA resistance was 41.9% with impedance aggregometry, and after determining the serum thromboxane B-2 level this percentage was only 8.6%. The correlation between these two methods was weak (r = 0.443; P&lt;0.0001). Thromboembolic complications still occur in ASA-treated patients because some patients are resistant to ASA therapy. It would be useful to monitor the effectiveness of ASA therapy and give another antiaggregation drug to these patients to reduce adverse events. The problem is which test is ideal because different tests show different percentages of ASA resistance. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30205 - Hematology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

BLOOD COAGULATION &amp; FIBRINOLYSIS

ISSN

0957-5235

e-ISSN

—

Volume of the periodical

27

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

4

Pages from-to

370-373

UT code for WoS article

000375857700003

EID of the result in the Scopus database

2-s2.0-84947461597