Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00124650" target="_blank" >RIV/00216224:14110/16:00124650 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1056872715004912?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1056872715004912?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jdiacomp.2015.12.009" target="_blank" >10.1016/j.jdiacomp.2015.12.009</a>

Result language

angličtina

Original language name

Association of serum N-epsilon-Carboxy methyl lysine with severity of diabetic retinopathy

Original language description

Purpose: To correlate serum levels of N-epsilon-carboxy methyl lysine (N-epsilon-CML) with severity of retinopathy, in vivo macular edema and disruption of external limiting membrane (ELM) and photoreceptor ellipsoid zone in type 2 diabetes mellitus (DM). Methods: Consecutive cases of type 2 DM [diabetes mellitus with no retinopathy (No DR) (n = 20); non proliferative diabetic retinopathy (NPDR) with diabetic macular edema (n = 20); proliferative diabetic retinopathy with diabetic macular edema (PDR) (n = 20)] and healthy controls (n = 20) between the ages of 40 and 65 years were included (power of study = 93.8%). In vivo histology of retinal layers was assessed using spectral domain optical coherence tomography. Every study subject underwent macular thickness analysis using the macular cube 512 x 128 feature. Disruption of ELM and photoreceptor ellipsoid zone was graded: grade 0, no disruption of ELM and ellipsoid zone; grade 1, ELM disrupted and ellipsoid zone intact; grade 2, both ELM and ellipsoid zone disrupted. Data were statistically analyzed. Results: The mean levels of N-epsilon-CML were 31.34 +/- 21.23 ng/ml, 73.88 +/- 35.01 ng/ml, 91.21 +/- 66.65 ng/ml, and 132.08 +/- 84.07 ng/ml in control, No DR, NPDR and PDR respectively. N-epsilon-CML level was significantly different between the study groups (control, No DR, NPDR and PDR) (p &lt; 0.001). Mean logMAR visual acuity decreased with increased levels of N-epsilon-CML (p &lt; 0.001). The association of (NCML)-C-epsilon with the grades of disruption was found to be statistically significant (F value = 18.48, p &lt; 0.001). Univariate analysis was done with N-epsilon-CML as a dependent variable. The values of N-epsilon-CML were normalized (log(10)) and were subjected to univariate analysis with fasting blood glucose level, glycosylated hemoglobin, central subfield macular thickness and cube average thickness among the diseased groups (NPDR and PDR) that act as confounders. It was found that none of the variables had significant effect on N-epsilon-CML (fasting blood glucose p = 0.12, HBA1c p = 0.65, central subfield macular thickness p = 0.13, cube average thickness p = 0.19). N-epsilon-CML tends to be a significant and important predictor of grade of ELM and ellipsoid zone disruption in diabetic retinopathy. Conclusions: Increased N-epsilon-CML levels are associated with increased severity of diabetic retinopathy, macular edema and structural changes in macula that is ELM and ellipsoid zone disruption, which serves as a prognosticator of visual outcome. (C) 2016 Elsevier Inc. All rights reserved.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30202 - Endocrinology and metabolism (including diabetes, hormones)

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Diabetes and its Complications

ISSN

1056-8727

e-ISSN

1873-460X

Volume of the periodical

30

Issue of the periodical within the volume

3

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

511-517

UT code for WoS article

000372940300021

EID of the result in the Scopus database

2-s2.0-84953439131